Tara Karnezis Selected Research

Vascular Endothelial Growth Factor D

12/2016	Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D.
8/2013	Signaling for lymphangiogenesis via VEGFR-3 is required for the early events of metastasis.
8/2013	Vascular endothelial growth factor-d modulates caliber and function of initial lymphatics in the dermis.
3/2013	The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology.
3/2013	Tumor location and nature of lymphatic vessels are key determinants of cancer metastasis.
8/2012	The connection between lymphangiogenic signalling and prostaglandin biology: a missing link in the metastatic pathway.
2/2012	VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium.
10/2011	A role for bone morphogenetic protein-4 in lymph node vascular remodeling and primary tumor growth.
8/2011	Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer.
4/2007	Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.

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Tara Karnezis Research Topics

Disease

14	Neoplasms (Cancer) 04/2022 - 04/2007
7	Neoplasm Metastasis (Metastasis) 12/2016 - 04/2007
5	Lymphatic Metastasis 01/2019 - 08/2011
2	Lymphedema (Milroy Disease) 12/2016 - 03/2014
2	Hypotrichosis 03/2014 - 12/2008
2	Telangiectasis (Telangiectasia) 03/2014 - 12/2008
1	Radiation Injuries (Radiation Sickness) 04/2022
1	Soft Tissue Injuries (Soft Tissue Injury) 04/2022
1	Hemangioma (Angioma) 01/2022
1	Lipedema 01/2022
1	Inflammation (Inflammations) 10/2017
1	Virus Diseases (Viral Diseases) 10/2017
1	Contact Dermatitis (Eczema, Contact) 10/2017
1	Wounds and Injuries (Trauma) 08/2013
1	Vascular Remodeling 10/2011
1	Multiple Sclerosis 09/2010
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2010
1	Spinal Cord Injuries (Spinal Cord Injury) 09/2006
1	Demyelinating Diseases (Demyelinating Disease) 09/2006

Drug/Important Bio-Agent (IBA)

10	Vascular Endothelial Growth Factor DIBA 12/2016 - 04/2007
5	EnzymesIBA 12/2016 - 04/2007
5	Vascular Endothelial Growth Factor CIBA 12/2016 - 02/2012
4	Messenger RNA (mRNA)IBA 04/2022 - 10/2011
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019 - 02/2012
4	Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA 12/2016 - 08/2011
3	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2007
3	ProstaglandinsIBA 12/2016 - 02/2012
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2014 - 08/2012
2	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 08/2013 - 08/2011
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 08/2012 - 02/2012
1	Propranolol (Inderal)FDA LinkGeneric 01/2022
1	Histones (Histone)IBA 01/2022
1	Atenolol (Tenormin)FDA LinkGeneric 01/2022
1	LipidsIBA 01/2022
1	Chemokine ReceptorsIBA 01/2019
1	ChemokinesIBA 01/2019
1	CCR10 ReceptorsIBA 01/2019
1	CytokinesIBA 01/2019
1	Glycoproteins (Glycoprotein)IBA 12/2016
1	Therapeutic UsesIBA 12/2013
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 03/2013
1	Heparin (Liquaemin)FDA LinkGeneric 03/2013
1	Indicators and Reagents (Reagents)IBA 03/2013
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 08/2012
1	MitogensIBA 08/2011
1	Transcription Factors (Transcription Factor)IBA 12/2008
1	Matrix Metalloproteinases (MMPs)IBA 04/2007
1	Leukemia Inhibitory FactorIBA 09/2006
1	Myelin Basic ProteinIBA 09/2006

Therapy/Procedure

6	Therapeutics 01/2022 - 09/2010
2	Radiotherapy 04/2022 - 03/2020
1	Synchrotrons 01/2010